NOT KNOWN DETAILS ABOUT PKRRATING

The activated enzyme then phosphorylates its key substrate, the translational initiation component eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to your conserved relatives of 4 protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in response to diverse stimuli12, triggering the built-in tens